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    This combination medication is used to relieve moderate to severe pain. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.

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  3. Jessica

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    Meridia is a drug that is taken by people who are obese. The drug affects the chemicals that are present inside the brain and are responsible for weight balancing. Generally, Meridia is the brand drug name that is also available in the market by a generic name called Sibutramine. Generic drugs are comparatively lesser in price to the brand versions of the same drug.

    The drug, Meridia, is mainly prescribed to people who are over-weight. For them, it may not be easy to maintain their physique with just dieting. This drug should only be taken along with proper diet and regular exercise. Doctors prescribe this drug to patients who suffer from diabetes, high cholesterol, or blood pressure problems. It is important for them to lose weight; otherwise, they may not be able to overcome these health problems.



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    There are some interesting facts about Meridia that people may not be aware of at the time of purchase. Some of them are listed below –

    Meridia, also known as Sibutramine, was withdrawn (discontinued) from the market in the year 2010.

    People have a myth regarding Meridia that a single drug will help them lose weight. Along with this medicine, you must include exercise and proper diet.

    It is observed that Meridia helped people with obesity by making them lose 10% of the weight. The average time that took them was around six to 11 months.

    The use of Meridia was first approved by the FDA in the year 1997.

    The work of Meridia is to increase serotonin availability, which is a chemical circulating in the brain.

    Meridia works quite similar to Fenfluramine that was taken within a few months when Meridia was introduced. Unlike Fenfluramine, Meridia effect in a more localized system. This was the reason that Meridia was considered a safer drug than Fenfluramine.



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    How do Meridia works?

    Meridia is a type of drug that helps obese people to cut down weight along with other treatments. The drug works by altering the neurotransmitters already available inside the brain of a human system. Neurotransmitters are classified as naturally occurring chemicals in a human brain. They are produced and released by the nerves so that they could stay connected to the other nerves.

    Is Meridia Back On Market?

    Meridia acts by blocking the absorption of neurotransmitters such as – dopamine, serotonin, and norepinephrine. This blocking is done so that the neurotransmitters change the balance within the nerve cells. This, in turn, affects the functioning of the nerves and its interaction. Patients are advised to take Meridia as per the guidelines mentioned in the prescription. Once Media

    If a person takes Meridia without taking a proper consultation from a health expert, the drug will have side effects that can be life-threatening. Doctors that prescribe for the use of Meridia have diagnosed the person and are suggesting for the dose that will help them manage the weight.

    Precautionary measures for Meridia:

    Below we have listed some of the safety measures that you may consider before using Meridia –

    Do remember to take Meridia after taking consultation from a health expert. You must not take Meridia on your own for daily use.

    Do not use Meridia if you are taking any other drug from earlier. Taking Meridia, along with other drugs, may result in drug interactions that can be harmful.

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    Patients who are younger than 16 years and older than 65 are not supposed to take Meridia.

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  5. Jessica

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    Methadone is a generic medication developed in Germany from 1937 to 1939. It was approved in the USA in 1947 for medical use. Methadone is also on the List of Essential Medicines by World Health Organization, which contains only those medicines that are safe and the most effective medications needed in the health system.

    Methadone is a strong synthetic analgesic similar to morphine in its effects but less sedative than morphine. Methadone oral tablets are available as brand name drugs under the names Methadose and Dolophine.

    Methadone comes in several formulations such as a tablet, dispersible tablet, solution, and concentrated solution. It also comes in injection only for administration by doctors.


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    Methadone is an opiate used in the treatment of opioid maintenance in opioid dependence and chronic pain.

    Methadone detoxifies in opioid dependence in less than a month. A single dose of the medication has a rapid effect, and it reaches its maximum effectiveness within five days of use.

    Pain-relieving effects of Methadone starts as soon as 20 to 30 minutes after a single dose and last for about six hours. After a long term use of Methadone, pain relief lasts for 8 to 36 hours in people with normal liver functioning.

    Methadone is mainly for the management of:

    Methadone Maintenance:

    Methadone helps treat opioid use disorder. It is useful both as maintenance therapy or a short period detoxification for managing opioid withdrawal symptoms.

    Methadone treatment programs for opioid maintenance or detoxification ranges from a few months to several years.

    The main goals of maintenance are to suppress the abstinence syndrome, relieve opioid cravings, and block the euphoric effects of opioids.

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    Methadone is an approved medication for the treatment of opioid addiction in many parts of the world, including America.

    The use of Methadone for treating addiction is strictly regulated. Outpatient treatment plans must be certified by the federal Substance Abuse and Mental Health Services Administration (SAMHSA) and registered by the DEA (Drug Enforcement Administration) in the USA.

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    Methadone is a useful analgesic in chronic pain.

    Methadone is active at the NMDA receptor that makes it more useful for neuropathic pain. Due to the same reason, Methadone tolerance effects are less than that of other opioid analgesics.

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    For short term moderate to severe pain:
    The usual adult dosage for the management of mild pain initiates with 2.5 milligrams given every 8 to 12 hours, as needed. Slowly titrate the dose at an interval of three to five days to achieve maximum beneficial effects.

    For detoxification of opioid addiction:

    The starting dose for detoxification of opioid addiction is 20 to 30 milligrams. After a duration of two to four hours, the doctor may give you an additional 5-10 milligrams dose if required. Do not surpass more than 40 milligrams dose on the first day.

    For maintenance of opioid addiction: The usual adult dosage for maintenance of opioid addiction ranges from 80 to 120 milligrams per day. A doctor will adjust and titrate the doses as required by the patient to achieve maximum therapeutic effects.

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    Below are some precautions to follow before taking Methadone:

    Tell your doctor if you have a hypersensitivity to Methadone, any other opioids, or any inactive ingredients of Methadone pills.
    Inform your doctor about all the concurrent medications, supplements, vitamins, or any herbal products that you are taking.
    Consult to the doctor about your medical status, ever had an intestinal blockage or paralytic ileus, difficulty urinating, an enlarged prostate in males, Addison’s disease, thyroid, seizures, and pancreas, gall bladder, kidney, or liver diseases.
    Methadone passes through breast milk. Inform your doctor if you are a breastfeeding mother. The lactating baby may develop difficulty sleeping or breathing, and withdrawal symptoms.
    Methadone may decrease fertility in men and women. Talk to your doctor before taking the medication.
    Tell your dentists that you are on Methadone medication if you are going to have dental surgery.
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    Abruptly stopping the medication of Methadone may cause withdrawal symptoms. The symptoms of Methadone withdrawal are more significant than symptoms of other opioids with shorter half-lives.

    Physical symptoms of Methadone withdrawal include lightheadedness, tears in eyes, dilated pupils, sensitivity to light, slow or shallow breathing, runny nose, nausea, vomiting, diarrhea, fever, sweating, chills, tremors, pain in joints and legs, elevated pain sensitivity, high blood pressure, and fast heart rate.

    Cognitive symptoms of withdrawal with Methadone include suicidal thoughts, depression, spontaneous orgasm, insomnia, delirium tremens, auditory or visual hallucinations, increase or decrease in sex drive, agitation, anxiety, nervousness, paranoia, delusions, and anorexia.

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    Prevent Methadone withdrawal by gradually tapering the doses when there is a need to discontinue the treatment. If withdrawal symptoms develop, consult a doctor about their treatment. Following are the ways to prevent and treat withdrawal:

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